Sonic Hedgehog Signaling Induces Vascular Smooth Muscle Cell Proliferation via Induction of the G 1 Cyclin-Retinoblastoma Axis
نویسندگان
چکیده
منابع مشابه
Sonic hedgehog signaling induces vascular smooth muscle cell proliferation via induction of the G1 cyclin-retinoblastoma axis.
OBJECTIVE Proliferation of vascular smooth muscle cells (VSMCs) is a crucial event in the pathogenesis of intimal hyperplasia, the main cause of restenosis following vascular reconstruction. Here, the impact of sonic hedgehog (Shh)/Gli family zinc finger 2 (Gli2) signaling on VSMC proliferation was assessed. METHODS AND RESULTS Increased Shh signaling was detected in VSMCs in the neointima of...
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OBJECTIVE Notch, VEGF, and components of the Hedgehog (Hh) signaling pathway have been implicated in vascular morphogenesis. The role of Notch in mediating hedgehog control of adult vascular smooth muscle cell (SMC) growth and survival remains unexplored. METHODS AND RESULTS In cultured SMCs, activation of Hh signaling with recombinant rShh (3.5 mug/mL) or plasmid encoded Shh increased Ptc1 e...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2010
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.110.208520